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People who take nitrates (drugs commonly used to dilate the blood vessels in the heart for patients with coronary artery disease, such as nitroglycerin), either on a regular schedule or as needed, should not use these ED drugs.

While all diabetics should exercise, the timing of doing the exercises may impact the rebound effect of nighttime hypoglycemia.

Elderly patients should be cautious when taking this medication, as they may be more prone to side effects, particularly dizziness and low blood pressure.