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7 There is also a more severe form of retinopathy that can include cystoid macular edema, retinal hemorrhages and optic nerve edema, and is associated with vision loss buy nolvadex pct 126, 180 It is exactly equivalent to the way we evaluate colonic biopsies for adenomatous change and, as is the case for colonic adenomas, the cytologic atypia within the atypical hyperplasia reflects a clonal proliferation of cells with some but not all the mutations necessary for transformation to carcinoma